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CAS 2872-52-8 | Disperse Red 1

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Common NameDisperse Red 1
CAS Number2872-52-8Molecular Weight314.33900
Density1.23 g/cm3Boiling Point522.5ºC at 760 mmHg
Molecular FormulaC16H18N4O3Melting Point160-162 °C(lit.)
MSDSChineseUSAFlash Point269.8ºC
Symbol
GHS07
Signal WordWarning

Names

NameDisperse Red 1
SynonymMore Synonyms

Disperse Red 1 BiologicalActivity

DescriptionDisperse Red 1, an azobenzene derivative, is an azo textile dye extensively used for dyeing polyester fabrics in textile industry[1][2].
Related CatalogResearch Areas >>OthersSignaling Pathways >>Others >>Others
In VitroExposure of human lymphocytes and a human hepatoma (HepG2) cell line to Disperse Red 1 in vitro at concentrations of 1.0 μg/mL and 2.0 μg/mL increases the frequency of micronuclei and also causes mutations in the Salmonella assay (13 revertants/μg)[2].
In VivoTo assess the toxic effects of Disperse Red 1 (DR1), on reproduction, sexually mature male mice (Mus musculus, strain CF-1) are orally (gavage) treated with single doses of the compound (20-500 mg/kg). Disperse Red 1 treatment causes testicular toxicity, increases frequency of sperm with abnormal morphology and decreases fertility. An increased amount of DNA damage is also detected in testis cells 16.6 and 24.9 days after treatments with 100 and 500 mg/kg[2].
References

[1]. Laís da Silva Leite, et al. Monitoring Ecotoxicity of Disperse Red 1 Dye During photo-Fenton Degradation. Chemosphere. 2016 Apr;148:511-7.

[2]. Fábio Henrique Fernandes, et al. Disperse Red 1 (Textile Dye) Induces Cytotoxic and Genotoxic Effects in Mouse Germ Cells. Reprod Toxicol. 2015 Jun;53:75-81.

Chemical & Physical Properties

Density1.23 g/cm3
Boiling Point522.5ºC at 760 mmHg
Melting Point160-162 °C(lit.)
Molecular FormulaC16H18N4O3
Molecular Weight314.33900
Flash Point269.8ºC
Exact Mass314.13800
PSA94.01000
LogP4.35200
Vapour Pressure9.57E-12mmHg at 25°C
Index of Refraction1.602
InChIKeyFOQABOMYTOFLPZ-UHFFFAOYSA-N
SMILESCCN(CCO)c1ccc(N=Nc2ccc([N+](=O)[O-])cc2)cc1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KL0320000
CHEMICAL NAME :
Ethanol, 2-(ethyl(4-((4-nitrophenyl)azo)phenyl)amino)- (9CI)
CAS REGISTRY NUMBER :
2872-52-8
LAST UPDATED :
199710
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C16-H18-N4-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7470 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 30(1),50,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 gm/kg/30D-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in erythrocyte (RBC) count
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 30(1),50,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2095 No. of Facilities: 479 (estimated) No. of Industries: 8 No. of Occupations: 11 No. of Employees: 6237 (estimated) No. of Female Employees: 279 (estimated)

Safety Information

Symbol
GHS07
Signal WordWarning
Hazard StatementsH317
Precautionary StatementsP280
Personal Protective Equipmentdust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard CodesXi:Irritant;
Risk PhrasesR43
Safety PhrasesS36/37
RIDADRNONH for all modes of transport
WGK Germany3
RTECSKL0320000
HS Code3204110000

Customs

HS Code2927000090
Summary2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles18

More Articles
Assessment of the sensitizing potential of textile disperse dyes and some of their metabolites by the loose-fit coculture-based sensitization assay (LCSA).

Arch. Toxicol. 86(5) , 733-40, (2012)

Certain textile disperse dyes are known to cause allergic reactions of the human skin. Here, we examined 8 disperse dyes and 7 products of azo-cleavage of these dyes in an in vitro assay. We used the ...

Chlorination treatment of aqueous samples reduces, but does not eliminate, the mutagenic effect of the azo dyes Disperse Red 1, Disperse Red 13 and Disperse Orange 1

Mutat. Res. 703(2) , 200-8, (2010)

The treatment of textile effluents by the conventional method based on activated sludge followed by a chlorination step is not usually an effective method to remove azo dyes, and can generate products...

Hepatotoxicity assessment of the azo dyes disperse orange 1 (DO1), disperse red 1 (DR1) and disperse red 13 (DR13) in HEPG2 cells.

J. Toxicol. Environ. Health A 75(16-17) , 991-9, (2012)

During the dyeing process in baths approximately 10 to 15% of the dyes used are lost and reach industrial effluents, thus polluting the environment. Studies showed that some classes of dyes, mainly az...

Synonyms

Amacel Scarlet GB
Acetate Fast Scarlet B
Dispersol Fast Scarlet B
Acetoquinone Light Scarlet BLZ
2-[N-ethyl-4-[(4-nitrophenyl)diazenyl]anilino]ethanol
4-[Ethyl(2-hydroxyethyl)amino]-4'-nitroazobenzene
EINECS 220-704-3
Dispersive Ruby Zh
Disperse Scarlet Zh
N-Ethyl-N-(2-hydroxyethyl)-4-(4-nitrophenylazo)aniline
Disperse Red Zh
Disperse Scarlet B
Acetamine Scarlet B
MFCD00007312

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