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| OEM | OEM Services Provided |
| Feature | Easy to Use Eco-friendly |
| Classification | Dyes and Pigments |
| Advantage | Professional, Fast Delivery, Customizable | Samples | Apply for free,Contact us now. |
| Common Name | Basic Orange 14 | ||
|---|---|---|---|
| CAS Number | 10127-02-3 | Molecular Weight | 739.943 |
| Density | / | Boiling Point | 468.6ºC at 760 mmHg |
| Molecular Formula | C34H40Cl4N6Zn | Melting Point | 165 °C |
| MSDS | ChineseUSA | Flash Point | 237.2ºC |
| Symbol | GHS08 | Signal Word | Warning |
| Name | Basic Orange 14 |
|---|---|
| Synonym | More Synonyms |
| Description | Acridine Orange (Euchrysine 3RX) zinc chloride salt is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange zinc chloride salt produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm)[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>Others |
| In Vitro | Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs)[4]. 1. 用 Acridine Orange zinc chloride salt 染色细胞 (1 μM; 20 分钟; 37 ℃)。 2. 用 PBS 洗涤细胞。 3. 通过共聚焦激光扫描显微镜 (FV3000,Olympus) 观察细胞。 |
| In Vivo | Acridine Orange (0.1 mg/kg,静脉注射,狗) zinc chloride salt 在 30 天内没有表现出临床毒性迹象,血液中也没有发现异常[1]。 |
| References | [1]. McMaster GK, et al. Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarosegels by using glyoxal and acridine orange. Proc Natl Acad Sci U S A. 1977 Nov;74(11):4835-8. [2]. Traganos F, et al. Simultaneous staining of ribonucleic and deoxyribonucleic acids in unfixed cells using acridine orange in a flow cytofluorometric system. J Histochem Cytochem. 1977 Jan;25(1):46-56. [3]. Byvaltsev VA, et al. Acridine Orange: A Review of Novel Applications for Surgical Cancer Imaging and Therapy. Front Oncol. 2019 Sep 24;9:925. [4]. Wang Q, et al. Substrate stiffness regulates the differentiation profile and functions of osteoclasts via cytoskeletal arrangement. Cell Prolif. 2022 Jan;55(1):e13172. |
| Boiling Point | 468.6ºC at 760 mmHg |
|---|---|
| Melting Point | 165 °C |
| Molecular Formula | C34H40Cl4N6Zn |
| Molecular Weight | 739.943 |
| Flash Point | 237.2ºC |
| Exact Mass | 736.135986 |
| PSA | 38.74000 |
| LogP | 10.02050 |
| InChIKey | VADJQOXWNSPOQA-UHFFFAOYSA-L |
| SMILES | CN(C)c1ccc2cc3ccc(N(C)C)cc3nc2c1.Cl.Cl[Zn]Cl |
| Storage condition | Store at RT. |
| Water Solubility | soluble |
| Symbol | GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H341 |
| Precautionary Statements | P281 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R20/21/22;R68 |
| Safety Phrases | S45-S36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | AR7600000 |
| Packaging Group | I; II; III |
| Hazard Class | 6.1 |
| HS Code | 32041300 |
| HS Code | 32041300 |
|---|
| Toward structured macroporous hydrogel composites: electron beam-initiated polymerization of layered cryogels. Biomacromolecules 16(4) , 1146-56, (2015) The ability to tailor mechanical properties and architecture is crucial in creating macroporous hydrogel scaffolds for tissue engineering. In the present work, a technique for the modification of the ... | |
| ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated with gambogic acid. PLoS ONE 9(5) , e96418, (2014) Gambogic acid (GA), the main active component of gamboge resin, has potent antitumor activity both in vivo and in vitro. However, the underlying molecular mechanisms remain unclear. In this study, we ... | |
| Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells. Autophagy 10(7) , 1179-92, (2014) Recent studies have indicated that cancer stem-like cells (CSCs) exhibit a high resistance to current therapeutic strategies, including photodynamic therapy (PDT), leading to the recurrence and progre... |
| N,N,N',N'-Tetramethyl-3,6-acridinediamine - dichlorozinc (2:1) dihydrochloride |
| Acridine Orange hemi(zinc chloride) salt |
| MFCD00081043 |
| zinc,3-N,3-N,6-N,6-N-tetramethylacridine-3,6-diamine,dichloride,hydrochloride |
| Acridine Orange |
| N,N,N',N'-Tetramethyl-3,6-acridinediamine - dichlorozinc hydrochloride (2:1:2) |
| Euchrysin GNY |
| EINECS 200-614-0 |
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