CAS 587-98-4 | Acid Yellow 36

[1]. Sharma UK, et al. Ameliorating efficacy of eugenol against metanil yellow induced toxicity in albino Wistar rats. Food Chem Toxicol. 2019;126:34-40.

[2]. Nakano N, et al. Development of a monitoring system for vinyl chloride gas in air by using an HCl monitoring tape and pyrolyzer. Talanta. 1996;43(3):459-463.

[3]. Ramchandani S, et al. Effect of oral and parenteral administration of metanil yellow on some hepatic and intestinal biochemical parameters. J Appl Toxicol. 1997;17(1):85-91.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

DB7329500

CHEMICAL NAME :

Benzenesulfonic acid, 3-((4-(phenylamino)phenyl)azo)-, monosodium salt

CAS REGISTRY NUMBER :

587-98-4

LAST UPDATED :

199709

DATA ITEMS CITED :

15

MOLECULAR FORMULA :

C18-H14-N3-O3-S.Na

MOLECULAR WEIGHT :

375.40

WISWESSER LINE NOTATION :

WSO&R CNUNR DMR &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1800 mg/kg/90D-C

TOXIC EFFECTS :

Brain and Coverings - other degenerative changes Autonomic Nervous System - sympathomimetic Behavioral - alteration of operant conditioning

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

6450 mg/kg/15D-I

TOXIC EFFECTS :

Gastrointestinal - other changes Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

240 mg/kg/3D-I

TOXIC EFFECTS :

Liver - other changes Biochemical - Metabolism (Intermediary) - lipids including transport

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

540 gm/kg/26W-C

TOXIC EFFECTS :

Blood - normocytic anemia Blood - changes in other cell count (unspecified) Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

162 gm/kg

SEX/DURATION :

male 90 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :

Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :

Rodent - mouse

DOSE/DURATION :

5 mg/kg

REFERENCE :

CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 31,299,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1438 No. of Facilities: 455 (estimated) No. of Industries: 10 No. of Occupations: 22 No. of Employees: 5070 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1438 No. of Facilities: 2370 (estimated) No. of Industries: 32 No. of Occupations: 33 No. of Employees: 52679 (estimated) No. of Female Employees: 18156 (estimated)

Biotech. Histochem. 83(3) , 147-51, (2008)

The cheek pouch is an anatomical peculiarity of hamsters, widely used as an experimental model for oral cancer, and characterization of its normal cell populations and the changes they undergo in path...

Se Pu 29(2) , 162-7, (2011)

A new method was established for the determination of 15 industrial synthetic dyes in condiment by solid phase extraction-high performance liquid chromatography (SPE-HPLC). The samples were extracted ...

Food Chem. Toxicol. 32(6) , 559-63, (1994)

The effects of Metanil yellow, Orange II and their blend on hepatic xenobiotic metabolizing enzymes were compared. Parenteral administration of Metanil yellow and Orange II to rats at a dose of 80 mg/...