CAS 2586-60-9 | Direct Violet 1

IC50: 1.47 µM (SARS-CoV-2-S-RBD binding to ACE2); 2.63 µM (SARS-CoV-S1S2 binding to ACE2); 2.11 µM (TNF-R1-TNFα binding)[1]

[1]. Damir Bojadzic, et al. Small-Molecule In Vitro Inhibitors of the Coronavirus Spike-ACE2 Protein-Protein Interaction as Blockers of Viral Attachment and Entry for SARS-CoV-2. bioRxiv, 2020 Oct 22.

[2]. Wafaa M Abd El-Rahim, et al. Genotoxicity studies on the removal of a direct textile dye by a fungal strain, in vivo, using micronucleus and RAPD-PCR techniques on male rats. J Appl Toxicol. 2008 May;28(4):484-90.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

QK1420000

CHEMICAL NAME :

2-Naphthalenesulfonic acid, 5,5'-(4,4'-biphenylylenebis(azo))bis(6-amino-4-hydrox y-, disodium salt

CAS REGISTRY NUMBER :

2586-60-9

LAST UPDATED :

198910

DATA ITEMS CITED :

2

MOLECULAR FORMULA :

C32-H22-N6-O8-S2.2Na

MOLECULAR WEIGHT :

728.70

WISWESSER LINE NOTATION :

L66J CZ HSWO JQ BNUNR DR DNUN- BL66J CZ HSWO JQ &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1125 gm/kg/71W-C

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Blood - leukemia

REFERENCE :

VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 23(7),72,1977

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

125 gm/kg/71W-C

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors Blood - tumors

REFERENCE :

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 22(10),22,1978