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| OEM | OEM Services Provided |
| Feature | Good stability,Easy to Use |
| Classification | Dyes and Pigments |
| Advantage | Professional, Fast Delivery, Customizable | Samples | Apply for free，Contact us now. |
| Product Name: | Acid Blue 90 |
| Synonyms: | abcolbrilliantcyanineblueg;COOMASSIE BRILLIANT BLUE G 250PURE;SERVA BLUE GRESEARCH GRADE;Coomassie Brilliant Blue G250 (C.I. 42655) pure;COOMASSIE (R) BRILLANT BLUE;ACID BLUE 90;SERVA BLUE G;SERVA DENSISTAIN BLUE G STAINING SOLUTION |
| CAS: | 6104-58-1 |
| MF: | C47H48N3NaO7S2 |
| MW: | 854.02 |
| EINECS: | 228-058-4 |
| Product Categories: | Dyes and Pigments;BProtein Electrophoresis;Coomassie StainsPlant Proteomics;Protein Detection;Protein Staining Reagents;Protein Stains and Staining Reagents;Stains and Dyes;Stains&Dyes, A to;Organics;Biochemistry;Reagents for Electrophoresis;marker |
| Mol File: | 6104-58-1.mol |
| Melting point | 100 °C |
| density | 1.274[at 20℃] |
| bulk density | 520kg/m3 |
| vapor pressure | 0.093Pa at 20℃ |
| Fp | 11 °C |
| storage temp. | 2-8°C |
| solubility | H2O: soluble1mg/mL |
| form | Solid |
| Colour Index | 42655 |
| color | Dark blue-violet-brown |
| PH | 6.4 (20°C, 10g/L in H2O) |
| Water Solubility | Soluble in water (50 mg/ml) and ethanol (40 mg/ml). |
| BRN | 5230822 |
| Stability: | Light Sensitive |
| InChIKey | JFNOCRSXNFZMNT-UHFFFAOYSA-M |
| LogP | -2.55 at 20℃ |
| CAS DataBase Reference | 6104-58-1(CAS DataBase Reference) |
| EPA Substance Registry System | C.I. Acid Blue 90 (6104-58-1) |
| Risk Statements | |
| Safety Statements | |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 32041200 |
| Provider | Language |
|---|---|
| N-[4-[[4-[(4-Ethoxyphenyl)amino]phenyl][4-[ethyl[(3-sulfophenyl)methyl]amino]-2-methylphenyl]methylene]-3-methyl-2,5-cyclohexadien-1-ylidene]-N-ethyl-3-sulfobenzenemethanaminium inner salt monosodium salt | English |
| ACROS | English |
| SigmaAldrich | English |
| ALFA | English |
| Chemical Properties | dark blue-violet-brown crystalline powder | |||||||||||||||||||||||||||||||||
| Brilliant Blue G is used in analytical biochemistry dye and as a P2X7 antagonist. It is also used in protein staining following gel electrophoresis. It is used to prepare the protein reagent for the determination of protein content of the collagenase enzyme isolated from fish waste. It may be employed as stain for the internal limiting membrane (ILM) for the macular hole (MH) and epiretinal membrane (ERM) surgery. It is useful for SDS gels as it readily stains proteins with minimal background color. Protein bands can be visualized during staining. It has been used in the Bradford dye-binding protein assay. A mechanism for dye binding to protein has been proposed, based on measuring Coomassie Brilliant Blue G-250 (CBBG) absorbance spectra during titration of the dye reagent in the absence of protein and its response to different polyamino acids. Brilliant Blue G has been used for determining critical micelle concentration of detergents. | ||||||||||||||||||||||||||||||||||
| Preparation | Benzaldehyde ?(1 Moore) and N-ethyl-N-benzyl-3-methylaniline?(2 Moore) condensation, And then sulfonating the product of three acids, and lead oxide, peroxide, and then the reaction with the 4-Ethoxybenzenamine, Benzaldehyde ?sulfonic acid groups on the phenyl ring is substituted anilino-ethoxy. | |||||||||||||||||||||||||||||||||
| Brilliant Blue G (BBG) is a dye. It has been proposed as a substitute for internal limiting membrane (ILM) peeling. | ||||||||||||||||||||||||||||||||||
| Flammability and Explosibility | Not classified | |||||||||||||||||||||||||||||||||
| brilliant blue g is also a selective inhibitor of the p2x purinoceptor channel p2x7 [1].p2x receptors are membrane ion channels activated in response to the binding of extracellular atp. seven p2x subtypes have been identified. p2x receptors have been involved in in diverse patho- and physiological processes, such as the autonomic nervous system, afferent signalling, chronic pain, and in autocrine loops of endothelial and epithelial cells. the p2x7 receptor plays a prominent role in certain neurologic disorders, such as ischemia-reperfusion injury, alzheimer's disease, spinal cord injury and sensory neuropathies [2].in hek293 cells heterologously expressing human p2x7 receptors, brilliant blue g noncompetitively inhibited rat and human p2x7 receptors with ic50 values of 10 and 200 nm, respectively. the ic50 values for inhibition of the other p2x receptors ranged from 2 to >30 μm; brilliant blue g inhibited the rat and human p2x4 receptors with the ic50 values of >10 and 3.2 μm [1]. subretinal injection of bbg caused retinal cell degeneration at lower concentrations. subretinal injection of bbg (0.25 mg/ml) provided satisfactory biocompatibility [3]. | ||||||||||||||||||||||||||||||||||
| Biochem/physiol Actions | P2X7 purinergic receptor antagonist. | |||||||||||||||||||||||||||||||||
| Room temperature | ||||||||||||||||||||||||||||||||||
| Properties and Applications | bright blue. Dark brown powder, slightly soluble in water, soluble in hot water (bright blue) and ethanol (bright blue). When a blood-red of sulfuric acid, a orange red after diluted. Its water solution and sodium hydroxide for purple. Used for wool and silk dyeing, also can be used for leather dyeing.
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| [1] jiang l h, mackenzie a b, north r a, et al. brilliant blue g selectively blocks atp-gated rat p2x7 receptors[j]. molecular pharmacology, 2000, 58(1): 82-88. [2] sperlágh b, vizi e s, wirkner k, et al. p2x 7 receptors in the nervous system[j]. progress in neurobiology, 2006, 78(6): 327-346. [3] ueno a, hisatomi t, enaida h, et al. biocompatibility of brilliant blue g in a rat model of subretinal injection[j]. retina, 2007, 27(4): 499-504. | ||||||||||||||||||||||||||||||||||
| Raw materials | Benzaldehyde-->Phenetidine-->Ethylbenzyltoluidine-->Phenetidine-->Ethylbenzyltoluidine-->Benzaldehyde |
| Preparation Products | Erioglaucine disodium salt-->ACID BLUE 9 ALUMINUM LAKE |
Declaration: The products displayed on this website are intended exclusively for industrial applications or scientific research. They are not intended for medical, pharmaceutical, or food use. In accordance with applicable laws and regulations, purchasing organizations must hold valid qualifications and approvals.
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