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CAS 25086-89-9 | Poly(1-vinylpyrrolidone-co-vinyl acetate)

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Common NamePoly(1-vinylpyrrolidone-co-vinyl acetate)
CAS Number25086-89-9Molecular Weight486.726
Density1.0±0.1 g/cm3Boiling Point536.7±50.0 °C at 760 mmHg
Molecular Formula(C6H9NO.C4H6O2)nMelting Point/
MSDSUSAFlash Point254.7±28.5 °C
Symbol
GHS07
Signal WordWarning

Names

NamePoly(1-vinylpyrrolidone-co-vinyl acetate)
SynonymMore Synonyms

BiologicalActivity

DescriptionCopovidone can be used as an excipient, such as Film formers, adhesives, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1].
Related CatalogResearch Areas >>OthersSignaling Pathways >>Others >>Others
References

[1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

Chemical & Physical Properties

Density1.0±0.1 g/cm3
Boiling Point536.7±50.0 °C at 760 mmHg
Molecular Formula(C6H9NO.C4H6O2)n
Molecular Weight486.726
Flash Point254.7±28.5 °C
Exact Mass486.370911
PSA46.61000
LogP9.76
Vapour Pressure0.0±1.4 mmHg at 25°C
Index of Refraction1.517
InChIKeyFYUWIEKAVLOHSE-UHFFFAOYSA-N
SMILESC=CN1CCCC1=O.C=COC(C)=O
StabilityStable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AH3539000
CHEMICAL NAME :
Acetic acid, ethenyl ester, polymer with 1-ethenyl-2-pyrrolidinone
CAS REGISTRY NUMBER :
25086-89-9
LAST UPDATED :
199710
DATA ITEMS CITED :
4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>630 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 2(5),141,1983

Safety Information

Symbol
GHS07
Signal WordWarning
Hazard StatementsH302
Precautionary StatementsP301 + P312 + P330
Personal Protective EquipmentEyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard CodesXi
Risk PhrasesR10
Safety PhrasesS22-S24/25
RIDADRUN 1987 3/PG 2
WGK Germany1
RTECSAH3539000
Packaging GroupII
Hazard Class3.0

Synonyms

copolyvidone
kolima35
gaf-s630
Cholest-8(14)-ene-3,6-diyl diacetate
kolima10
s630
Cholest-8(14)-ene-3,6-diol, diacetate
MFCD00134018
pvp-va
VP/VA Copolymers Powder

Declaration: The products displayed on this website are intended exclusively for industrial applications or scientific research. They are not intended for medical, pharmaceutical, or food use. In accordance with applicable laws and regulations, purchasing organizations must hold valid qualifications and approvals.

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