CAS 118-82-1 | 4,4'-Methylenebis(2,6-di-tert-butylphenol)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

SL9650000

CHEMICAL NAME :

Phenol, 4,4'-methylenebis(2,6-bis(1,1-dimethylethyl)-

CAS REGISTRY NUMBER :

118-82-1

BEILSTEIN REFERENCE NO. :

1916919

LAST UPDATED :

199710

DATA ITEMS CITED :

5

MOLECULAR FORMULA :

C29-H44-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2021 mg/kg/1W-C

TOXIC EFFECTS :

Liver - other changes Blood - other changes Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :

TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 8,77,1981

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

56700 mg/kg/2Y-C

TOXIC EFFECTS :

Gastrointestinal - ulceration or bleeding from large intestine Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring) Related to Chronic Data - death

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536073 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83032 No. of Facilities: 7725 (estimated) No. of Industries: 96 No. of Occupations: 64 No. of Employees: 120009 (estimated) No. of Female Employees: 20306 (estimated)

Toxicol. Lett. 8(1-2) , 77-86, (1981)

Hepatic lipids were studied in Sprague-Dawley male rats given, 2,2'-methylenebis(4-ethyl-6-tert-butylphenol), 2,2'-methylenebis(4-methyl-6-tert-butylphenol), 4,4'-butylidenebis(3-methyl-6-tert-butylph...