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| OEM | OEM Services Provided |
| Feature | Good stability,Easy to Use |
| Classification | Catalysts and Additives |
| Advantage | Professional, Fast Delivery, Customizable | Samples | Apply for free，Contact us now. |
| Common Name | m-PEG-OH (MW 2000) | ||
|---|---|---|---|
| CAS Number | 9004-74-4 | Molecular Weight | 516.620 |
| Density | 1.08 | Boiling Point | 557.1±45.0 °C at 760 mmHg |
| Molecular Formula | C23H48O12 | Melting Point | 12 ºC |
| MSDS | ChineseUSA | Flash Point | 268 ºC |
| Name | methoxypoly(ethylene glycol) |
|---|---|
| Synonym | More Synonyms |
| Description | m-PEG-OH (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
| Target | PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
| Density | 1.08 |
|---|---|
| Boiling Point | 557.1±45.0 °C at 760 mmHg |
| Melting Point | 12 ºC |
| Molecular Formula | C23H48O12 |
| Molecular Weight | 516.620 |
| Flash Point | 268 ºC |
| Exact Mass | 516.314575 |
| LogP | -4.38 |
| Appearance of Characters | semisolid | White to pale yellow |
| Vapour density | >1 (vs air) |
| Vapour Pressure | 0.0±3.4 mmHg at 25°C |
| Index of Refraction | 1.456 |
| Storage condition | ?20°C |
| Water Solubility | H2O: 50 mg/mL at 25 °C, clear, colorless |
| Personal Protective Equipment | Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | PE8271000 |
| Universal concept for the implementation of a single cleavable unit at tunable position in functional poly(ethylene glycol)s. Biomacromolecules 14(2) , 448-59, (2013) Poly(ethylene glycol) (PEG) with acid-sensitive moieties gained attention particularly for various biomedical applications, such as the covalent attachment of PEG (PEGylation) to protein therapeutics,... | |
| Preliminary assessment of the safety evaluation of novel pH-sensitive hydrogel. Eur. J. Pharm. Biopharm. 82(2) , 332-9, (2012) In our previous work, a new kind of pH-sensitive hydrogel based on poly (lactic acid) (PLA), methoxyl poly (ethylene glycol) (MPEG) and itaconic acid (IA) was prepared by heat-initiated free radical p... | |
| PEGylation of vesicular stomatitis virus extends virus persistence in blood circulation of passively immunized mice. J. Virol. 87(7) , 3752-9, (2013) We are developing oncolytic vesicular stomatitis viruses (VSVs) for systemic treatment of multiple myeloma, an incurable malignancy of antibody-secreting plasma cells that are specifically localized i... |
| MFCD00084416 |
| Poly(oxy-1,2-ethanediyl), α-methyl-ω-hydroxy- Polymer |
| 2,5,8,11,14,17,20,23,26,29,32-Undecaoxatetratriacontan-34-ol |
| Methoxypolyethylene glycols |
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