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AURAMINE O | CAS 2465-27-2

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AURAMINE O Basic information

Product Name:AURAMINE O
Synonyms:PYOCTANINUM AUREUM;PYOCTANUNUM AUREUM;PYOKTANIN YELLOW;PYKOTANNIN;AURAMINE O, CERTIFIED;AURAMINE O, CERTIFIED (C.I. 41000);AURAMINE O, FOR MICROSCOPY;BASIC YELLOW 2
CAS:2465-27-2
MF:C17H22ClN3
MW:303.83
EINECS:219-567-2
Product Categories:Organics;Dyes and Pigments;Diphenylmethane
Mol File:2465-27-2.mol

AURAMINE O Chemical Properties

Melting point >250 °C (dec.)(lit.)
bulk density430kg/m3
storage temp. Inert atmosphere,Room Temperature
solubility 10g/l
form Powder/Solid
pka9.8, 10.7(at 25℃)
Colour Index 41000
color Yellow to ochre-yellow
PH Range6.5
PH6-7 (10g/l, H2O, 20℃)
Water Solubility Soluble in water or ethanol
λmax370 nm, 432 nm
ε(extinction coefficient)≥12000 at 249-255nm in water at 0.005g/L
≥15000 at 367-373nm in water at 0.005g/L
≥36000 at 429-435nm in water at 0.005g/L
BRN 4030061
Stability:Stable. Incompatible with strong oxidizing agents.
Biological ApplicationsDetecting bacteria; treatment of cancers,cardiovascular disease,diabetesassociated pain,mechanical allodynia,metabolic syndrome,protozoan infections in fish; targeted drug delivery; as fungal inhibitors
CAS DataBase Reference2465-27-2(CAS DataBase Reference)
NIST Chemistry ReferenceAniline, 4,4'-(imidocarbonyl)bis-(n,n-dimethyl)-, hydrochloride(2465-27-2)
EPA Substance Registry SystemAuramine, monohydrochloride (2465-27-2)

Safety Information

Hazard Codes T,Xn
Risk Statements 22-24-40-20/21/22
Safety Statements 36/37-45-36-22
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS BY3675000
TSCA Yes
HS Code 3204 13 00
HazardClass 6.1
PackingGroup III
Hazardous Substances Data2465-27-2(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 1000 mg/kg

MSDS Information

ProviderLanguage
ACROS English
SigmaAldrich English

AURAMINE O Usage And Synthesis

Chemical PropertiesUsesGeneral DescriptionReactivity ProfileFire HazardPotential ExposureProperties and ApplicationsIncompatibilities
Chemical Propertiesyellow powder
Auramine is a yellow crystalline powder orflaky material.
UsesCertified for use by fluorescence microscopy in Churukian's modification of Truant's fluorescent method for acid fast bacilli on paraffin sections.
Fluorescent stain for acid-resistant bacteria in sputum
DefinitionChEBI: A hydrochloride obtained by combining 4,4'-carbonimidoylbis(N,N-dimethylaniline) with one molar equivalent of hydrogen chloride. A fluorescent stain for demonstrating acid fast organisms in a method similar to the Zieh Neelsen. It also can be used to make a fluorescent Schiff reagent.
Yellow flakes or powder.
Air & Water ReactionsInsoluble in water.
AURAMINE O is incompatible with strong oxidizing agents.
HazardProbable carcinogen.
Flash point data for AURAMINE O are not available. AURAMINE O is probably combustible.
Biological ActivityAuramine O is used for the staining of acid-fast organisms, coccidia. Auramine O along with carbol generates brilliant yellow fluorochrome of tubercle bacilli. It is effective in detecting positive cases of tuberculosis. Auramine O binds to the mycolic acid in the bacterial cell wall.
Auramine is used industrially as a dyeor dye intermediate for coloring textiles; paper, and leather.Also used as an antiseptic (a powerful antiseptic in ear andnose surgery, and treatment of gonorrhea) and fungicide.Human exposure to auramine occurs principally throughskin absorption or inhalation of vapors. Low-level dermalexposure to the consumer may occur but would be limitedto any migration of auramine from fabric, leather, or papergoods.
ShippingUN2811 Toxic solids, organic, n.o.s., HazardClass: 6.1; Labels: 6.1-Poisonous materials, TechnicalName Required. UN3143 Dyes, solid, toxic, n.o.s. or Dyeintermediates, solid, toxic, n.o.s., Hazard Class: 6.1;Labels: 6.1-Poisonous materials, Technical Name Required.

TEST ITEMS

SPECIFICATION

APPEARANCE

DARK YELLOWPOWDER

SHADE

BRIGHT YELLOWISH

HEAT RESISTANCE

280 °C min

DENSITY

1.07 g/cm 3

WATER FASTNESS

4-5

LIGHT FASTNESS

1-2

BLEACHABILITY (OXIDATIVE)

4

BLEACHABILITY (REDUCTIVE)

3

WATER SOLUBILITY AT 20 °C

10 g/L min

WATER INSOLUBLE

1.0% max

MOISTURE

3.0% max

TINTING STRENGTH

100-105 %

WEIGHT METAL TOTAL

50ppm max

Purification MethodsIt crystallises from EtOH as the hydrochloride and is very slightly soluble in CHCl3, UV: 434nm ( 370). The free base (carbinolamine) has m 136o (from *C6H6). [Goldacre & Phillips J Chem Soc 1724 1949, Conrad et al. Biochemistry 9 1540 1970, Beilstein 14 IV 256.]
Incompatible with oxidizers (chlorates,nitrates, peroxides, permanganates, perchlorates, chlorine,bromine, fluorine, etc.); contact may cause fires or explosions.Keep away from alkaline materials, strong bases,strong acids, oxoacids, epoxides.
Waste DisposalConsult with environmentalregulatory agencies for guidance on acceptable disposalpractices. Generators of waste containing this contaminant(≥100 kg/mo) must conform with EPA regulations governingstorage, transportation, treatment, and waste disposal.Incinerate in furnace with afterburner and scrubber.

AURAMINE O Preparation Products And Raw materials

Raw materialsN,N-Dimethylaniline-->Sulfanilic acid-->Benzhydrylamine-->N1,N1-DIETHYL-4-[4-(DIETHYLAMINO)BENZYL]ANILINE

Declaration: The products displayed on this website are intended exclusively for industrial applications or scientific research. They are not intended for medical, pharmaceutical, or food use. In accordance with applicable laws and regulations, purchasing organizations must hold valid qualifications and approvals.

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